SOUTH SAN FRANCISCO, San Mateo County — November 12, 2026. Motorists using U.S. Highway 101 in and around South San Francisco should prepare for continuing intermittent nighttime lane and ramp closures. Caltrans District 4 lists both northbound and southbound construction periods 9 p.m.–5 a.m. on weeknights through Tuesday, November 24, with an additional work date on Monday, November 30.
What is happening during the day?
Caltrans also lists some partial daytime ramp restrictions from 7 a.m. to 3 p.m. for accessibility improvements between South San Francisco and East Palo Alto. This is a long multi-city project area; the bulletin does not say every ramp in South San Francisco is closed every night or that all locations undergo work at once.
Why the highway is being upgraded
The $177 million US 101 Multi-Asset Rehabilitation and Roadside Safety Project includes paving, guardrail repairs, drainage and electrical work, transportation management improvements and ADA-compliant curb ramps. The agency says construction is funded through the state’s highway repair program and remains weather-dependent.
How to plan a trip
Before traveling, check the precise entry or exit ramp on Caltrans QuickMap, look for message boards and use marked detours rather than guessing which connection is open. A construction schedule is not proof of a current incident or a live road closure.
Source
Caltrans District 4, November 2, San Mateo US 101 advisory. Updates to lane and ramp restrictions will be reflected in the agency’s live travel system.
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